Effects of Rosa Canina L. fruit on glycemia and lipid profile in type 2 Diabetic Patients: a randomized, double-blind, placebo controlled clinical trial

Background: Rosa canina L. [rose hip] has been traditionally used to treat diabetes mellitus in Iran. However, no scientific human study has determined its efficacy in diabetic patients

Objective: This study was conducted to evaluate the efficacy and safety of R. canina fruit aqueous extract in type 2 diabetic patients

Methods: Sixty patients with type 2 diabetes, aged 35 - 60 years with fasting blood glucose levels between 130 to 200 mg/dL and HbA1c between 7 - 9% despite using conventional oral hypoglycemic drugs were divided randomly to two groups. Two groups of 25 and 23 patients completing the trial received 750 mg R. canina fruit extract and 750 mg toast powder as placebo two times a day respectively for three months. Fasting blood glucose [FBG] and glycosylated hemoglobin [HbA1c] as primary outcomes and postprandial blood glucose [PBG], lipid profile and hepatic and renal function tests as secondary outcomes were determined at baseline and at endpoint of treatment. The patients were asked to note down any gastrointestinal or other side effects during the study

Results: The FBG level decreased significantly [P = 0.002] in R. canina group after 3 months compared to the baseline. In addition total cholesterol/HDL-C was significantly [P = 0.02] decreased in the R. canina group compared to the baseline. Other blood parameters were not significantly changed during the study compared with placebo and baseline. No serious side effects were reported in both groups during the study

Conclusion: Rosa canina 3-month administration to type 2 diabetic patients may reduce fasting blood glucose and total cholesterol/HDL-C without any side effect

[Review of antidiabetic plants in Iranian traditional medicine and their efficacy]

High prevalence of diabetes mellitus and its complications and increasing use of complementary therapies, especially herbal therapies, and the need of developing countries to use their indigenous medical methods, motivated us to introduce some plants used in Iranian traditional medicine for the treatment of this disease. The topic of "ziabetes" [the synonym of diabetes] in some of Iranian traditional medical texts were studied and herbal therapies of this disease were collected. Some edible plant compounds introduced and scientific names of plants in these compounds were identified. Pubmed and Scopus databases were searched for studies regarding hypoglycemic effects of these medicinal herbs on animal or human subjects. Many medicinal herbs and; minerals in single or compound form have been used in Iranian traditional medicine. Plants such as Punica granatum, Rosa damascene, Plantago psyllium, Glycyrrhiza glabra, Coriandrum sativum, Portulaca oleracea and Rumex patientia are the most popular ones. Recent studies on animal or human subjects have shown the hypoglycemic effects of some of these plants. Reassessment of the effects of some antidiabetic plants used in Iranian traditional medicine, proved their efficacy mainly in animals. However, we need more clinical trials to prove safety and; efficacy of these herbs and compounds

Aloe vera leaf gel in treatment of advanced type 2 diabetes mellitus needing insulin therapy: a randomized double-blind placebo-controlled clinical trial

Advanced type 2 diabetes mellitus [T2DM] needing insulin therapy is a common disease. Previous studies indicate that aloe [Aloe vera L.] leaf gel may positively affect the blood glucose and lipid levels in patients with advanced T2DM needing insulin. Evaluation of the efficacy and safety of aloe leaf gel in the treatment of type 2 diabetic patients resistant to oral synthetic anti-hyperglycemic drugs needing insulin. In this randomized double - blind placebo-controlled clinical trial with the patients aged 40-60 years, the efficacy and safety of taking aloe leaf gel [one 300 mg capsule every 12 hours for 2 months] combined with oral synthetic anti-hyperglycemic drugs in treatment of 35 patients were evaluated and compared with the placebo group [n = 35]. The aloe leaf gel lowered the blood levels of fasting glucose and glycosylated hemoglobin significantly [p = 0.041 and p = 0.023 respectively] without any significant effects on the lipid profile and liver/kidney function tests [p > 0.05] compared with placebo at the endpoint. No adverse effects were reported. The results suggest that aloe leaf gel may safely improve glycemic control in patients with advanced T2DM needing insulin

Use and attitude on herbal medicine in a group of pregnant women in Tehran

While the use of herbal medicines is common in Tehran, there is scant data regarding various aspects of the use of such medicines during pregnancy. The frequency of the use of herbal medicines in a group of pregnant women in Tehran and their attitude to the use of such medicines were evaluated. In this cross-sectional study, 600 pregnant women were studied. A researcher-made questionnaire was used to explore the demographic and pregnancy related data, the extent of use of the herbal medicines, the subjects' sources of information and their attitude regarding such medicines. The data were analyzed using student t- and chi-square tests. Logistic regression was used to determine the predicting factors. 402 [67%] participants had used at least one type of herbal medicine during their current or previous pregnancies, with a mean of 2.71 +/- 1.94 herbs per individual. Two commonly used herbs were peppermint [32.8%] and olibanum [26.3%]. Maternal and Gestational age, family size, children number, frequency of having medical insurance and positive attitude in users were significantly higher than non-users [P values were 0.02, 0.02, 0.001, <0.001, 0.04 and <0.001 respectively]. The score of attitude was the only predictor for taking herbal medicine with the odds ratio 0.89 [95% confidence interval: 0.86-0.92] of logistic regression model for negative attitude. Considering the high frequency of herbal medicine use during pregnancy, pregnant women need appropriate sources of information about these medicines. Further, health care providers should ask pregnant women about taking herbal medicines